SABR-ROC


  • Introduce
  • Background
Dear Researchers,

Yong Bae Kim M.D. Principal Investigator, "SABR-ROC" Clinical Trial

Yonsei Cancer Center, Seoul, South Korea

As the principal investigator of the clinical trial "SABR-ROC" for recurrent ovarian cancer, I am writing to extend an invitation to potential participants who may be interested in contributing to this important research endeavor.
The "SABR-ROC" trial aims to evaluate the efficacy and safety of Stereotactic Ablative Radiotherapy (SABR) as a treatment modality for patients with recurrent ovarian cancer. Our objective is to explore the potential benefits of targeted radiotherapy in improving treatment outcomes and quality of life for individuals facing this challenging disease.

By participating in this trial, patients will have the opportunity to access a novel treatment approach while contributing to the advancement of medical knowledge in the field of ovarian cancer research.
If you or any of your patients are interested in participating in the "SABR-ROC" trial, I kindly request that you reach out to our research team at your earliest convenience. Our team will provide detailed information about the trial, explain the screening process, and address any questions or concerns you may have. Your participation in this trial is crucial to its success and the potential benefits it may offer to future patients. We value your collaboration and commitment to advancing ovarian cancer treatment options.
Thank you for your attention to this invitation. We look forward to the opportunity to work together in furthering our understanding of recurrent ovarian cancer and exploring innovative treatment approaches.

Yong Bae Kim M.D. Principal Investigator, "SABR-ROC" Clinical Trial

Yonsei Cancer Center, Seoul, South Korea

Background; Current status of ovarian cancer in Korea

Obstet Gynecol Sci 2021

  • 3rd most common gynecologic malignancy in Korea
  • Standard treatment is tumor debulking surgery +/- adjuvant chemotherapy
  • With a recurrence rate of 80%, the treatment results are the worst among gynecological cancers
  • A trend of extending survival according to the use of targeted and immune agents.
  • Long-term maintenance of chemotherapy is substantially difficult because recurrent tumors do not respond uniformly to chemotherapy and show mixed response
Background; History of RT in ovarian cancer
Radiotherapy Whole abdomen irradiation  WAI Involved field radiotherapy IFRT Stereotactic body radiotherapy SABR
Previous studies ㆍ1980~90s
ㆍNo benefit in survival over chemoTx
ㆍSerious effects
ㆍSingle center retrospective studies
ㆍProspective phase 2 ; KROG 14-05
ㆍGood efficacy and safety
ㆍSABR-COMET; ph2, solid tumors
ㆍ3 retrospective studies reported
ㆍGood efficacy and safety
Usage status Rarely used Currently used often Rapidly increasing use
Dose-fractions 24 Gy / 16 fx /
Additional treatment after 3 wks
50 Gy / 25 fx / 5 wks 24 Gy / 3 fx / 1 wk
Irradiated
&
treated volumes
Background; Current status of ovarian cancer in Korea
  • SABR is a preferable form of not interfering the schedule of systemic treatment by minimizing the elapsed days of radiotherapy.
  • A synergistic effect btw systemic Tx and SABR is expected to reduce the tumor burden by eradicating gross tumors identified by imaging with SABR and control microscopic cancer with systemic treatment.
  • Beneficial for QoL preservation in elderly or heavily treated patients
  • Prospective studies are needed to demonstrate the effectiveness of SABR